NUB1

NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene.[5][6][7]

NUB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUB1, BS4, NUB1L, NYREN18, negative regulator of ubiquitin-like proteins 1, negative regulator of ubiquitin like proteins 1
External IDsOMIM: 607981 MGI: 1889001 HomoloGene: 41108 GeneCards: NUB1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q36.1Start151,341,699 bp[1]
End151,378,449 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51667

53312

Ensembl

ENSG00000013374

ENSMUSG00000028954

UniProt

Q9Y5A7

P54729

RefSeq (mRNA)

NM_001243351
NM_016118
NM_001363529

NM_016736
NM_001305264

RefSeq (protein)

NP_001230280
NP_057202
NP_001350458

NP_001292193
NP_058016

Location (UCSC)Chr 7: 151.34 – 151.38 MbChr 5: 24.69 – 24.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM][7]

Interactions

NUB1 has been shown to interact with NEDD8,[8][9] UBD[8] and AIPL1.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000013374 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028954 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  6. Kito K, Yeh ET, Kamitani T (Jun 2001). "NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression". The Journal of Biological Chemistry. 276 (23): 20603–9. doi:10.1074/jbc.M100920200. PMID 11259415.
  7. "Entrez Gene: NUB1 negative regulator of ubiquitin-like proteins 1".
  8. Hipp MS, Raasi S, Groettrup M, Schmidtke G (Apr 2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". The Journal of Biological Chemistry. 279 (16): 16503–10. doi:10.1074/jbc.M310114200. PMID 14757770.
  9. Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (Dec 2001). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1". The Journal of Biological Chemistry. 276 (49): 46655–60. doi:10.1074/jbc.M108636200. PMID 11585840.
  10. Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM (Oct 2002). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Human Molecular Genetics. 11 (22): 2723–33. doi:10.1093/hmg/11.22.2723. PMC 2585502. PMID 12374762.

Further reading


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