SAM-IV riboswitch

SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM),[1] a cofactor used in many methylation reactions. Originally identified by bioinformatics,[2] SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct.

S-adenosyl methionine (SAM) riboswitch,
Identifiers
SymbolSAM-IV
RfamRF00634 CL00012
Other data
RNA typeCis-reg; riboswitch
Domain(s)Bacteria
SOSO:0005836
PDB structuresPDBe

See also

References

  1. Weinberg Z, Regulski EE, Hammond MC, et al. (2008). "The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches". RNA. 14 (5): 822–828. doi:10.1261/rna.988608. PMC 2327355. PMID 18369181.
  2. Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
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