Transcription elongation regulator 1

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[5][6][7]

TCERG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1
External IDsOMIM: 605409 MGI: 1926421 HomoloGene: 4879 GeneCards: TCERG1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q32Start146,447,311 bp[1]
End146,511,961 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10915

56070

Ensembl

ENSG00000113649

ENSMUSG00000024498

UniProt

O14776

Q8CGF7

RefSeq (mRNA)

NM_001040006
NM_006706
NM_001382548

NM_001039474
NM_001289526
NM_001360881

RefSeq (protein)

NP_001035095
NP_006697
NP_001369477

NP_001034563
NP_001276455
NP_001347810

Location (UCSC)Chr 5: 146.45 – 146.51 MbChr 18: 42.51 – 42.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[5]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1[8] and POLR2A.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000113649 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024498 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TCERG1 transcription elongation regulator 1".
  6. Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
  7. Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711. S2CID 2396234.
  8. Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
  9. Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. Bibcode:2000PNAS...97.9015C. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677.

Further reading


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