Phthalylsulfathiazole
Phthalylsulfathiazole (also known as sulfathalidine) belongs to the group of drugs called sulfonamides. The drug is a broad-spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase activity, which in turn leads to impaired synthesis of dihydrofolic acid and as a result its active metabolite necessary for the synthesis of purine and pyrimidine.
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ECHA InfoCard | 100.001.480 ![]() |
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Formula | C17H13N3O5S2 |
Molar mass | 403.43 g·mol−1 |
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The drug is indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is not absorbed into the blood stream from the gut due to extra n⁴ substitute. Adverse effects may include allergic reactions, vitamin B insufficiency, agranulocytosis and aplastic anemia.